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KMID : 0370220130570050309
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Yakhak Hoeji
2013 Volume.57 No. 5 p.309 ~ p.315
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Suppressive Effects of Cyanidin-3-glucoside on Th2 Cytokines Production in RBL-2H3 Cells
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Jeong Hwa-Hyun
Yoon Soo-Jeong
Pyo Myoung-Yun
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Abstract
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Cyanidin-3-glucoside (C3G), an anthocyanin, is one of the most widespread dietary flavonoids. We investigated the effects of C3G in PMA/ionomycin (PI)-induced RBL-2H3 cells. C3G inhibited the production of IL-4 and IL-13 and also decreased the level of mRNA in a dose-dependent manner. Furthermore, western blot analysis implied that C3G down-regulated the protein level of c-Jun, NF-ATc1 and NF-${\kappa}B$ 수식 이미지 but not c-Fos. Taken together, we suggest that C3G may have suppressive effects on Th2 cytokines and will be studied further to develop as functional foods that help alleviate allergy symptoms.
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KEYWORD
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cyanidin-3-glucoside, IL-4, IL-13, RBL-2H3 cells, antiallergy
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